B-cell colony growth of malignant and normal B-cells

B-cell growth factor receptor expression and B-cell growth factor response of leukemic B cell precursors and B lineage lymphoid progenitor cells.

The purpose of this study was to analyze the expression of B cell growth factor (BCGF) receptors and to elucidate the biologic effects of biochemically purified natural BCGF at the B cell precursor stage of human B lineage lymphoid differentiation. The specific binding of radioiodinated high-mol-wt BCGF (125I-HMW-BCGF) and low-molecular-wt BCGF (125I-LMW-BCGF) to fresh marrow blasts from B cell...

B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia.

Waldenström macroglobulinemia (WM) is a serious and frequently fatal B-cell malignancy associated with an elevated monoclonal IgM protein in the serum. Many of the mechanisms leading to this disease are not yet known. B-lymphocyte stimulator (BLyS) is a TNF family member that is critical for maintenance of normal B-cell development and homeostasis. BLyS is overexpressed in a variety of B-cell m...

A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells

B-cell superantigens (Sags) bind to conserved sites of the VH or VL regions of immunoglobulin molecules outside their complementarity-determining regions causing the apoptosis of normal cognate B cells. No attempts to investigate whether B-cell Sags are able to induce the apoptosis of cognate malignant B cells were reported. In the present study we show that protein L (PpL), secreted by Finegol...

Studies on normal B-cells and common acute lymphoblastic leukemia blast cells using a colony assay.

Normal and Malignant Liver Cell Growth

De Broc and colleagues have set out to produce a comprehensive handbook of chemical injury to the kidneys. The work is divided into three parts: a general section, dealing with clinical relevance, renal handling of drugs, immunological and cellular mechanisms, and a detailed exposition of experimental models; the main body of the work, discussing specific drugs; and a section on prevention incl...